I'd say that using a weight scale (as do the truckers) to see where the bus lives would be good start. FF/RR bias, Port/Starboard bias and any corrections needed. Proper tire pressures obtained as a result of certified weight scale tickets, also.
I might look into pre-warming the fluids: coolant, engine oil, maybe trans and axle oil with electric heaters.
Establishing a very high bar for maintenance (mechanical baseline) is worth more than most "mpg mods" as it directly affects reliability & longevity.
Really, for RV'ers here and elsewhere the idea of "economy" has more to do with how many nights one is aboard. And the distances covered annually. Vacationers really don't travel that much in comparison with those who live aboard.
And for those who live aboard (full-timers) the distances may not be that great either. Really, the "economy" can come down to not owning a house or paying high rents over long periods of time.
Situations differ so much that rules-of-thumb may be hard to come by.
But the best reading -- this is Ecomodder, after all -- will be of all threads by Orbywan in his pursuit of aerodynamic improvements on a Class C motorhome.
Welcome!!
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