I'm not Mr. Science, but I'm sure that it would help, as long as you also pay attention to the rear of the truck as many threads on here deal with.
I could only say if you are a hands on kind of guy, you could make a wood mockup of the frontend you want, and then have an experienced fiberglass guy make a mold from that.
Very spendy unless you can do at least some of it yourself.
A front end similar to this picture might be doable.
This is George Poteet's BLOWFISH: a '69 'Cuda set up for Bonneville.
If you google this, many more pics available.
The build story on the semi tractor was very interesting. It seemed a shame that at least they could have provided before and after mpg figures for the
tractor alone say at 55mph.!!!!