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Signs of serotonin syndrome

Irritability, Delirium, Loss of consciousness, Fits, Restlessness, Increased heart rate, Perspiration, Chill, Tremor, Mental status changes, Restlessness, Increased reflexes, Increased reflexes, Stiffness, Shaking, Pain in the abdomen, Diarrhea, Perspiration, Increased heat, Hypertension. Just about all these are symptoms of serotonin syndrome. All can come usually in the first 24 hours right after taking a great overdose of serotonin drugs. This signs or symptoms are on mental processes level, autonomic degree and also SoNS degree. Serotonin Toxidrome come often after o.d. of serotonin drugs and drug combination that increase synaptic serotonin. Drugs which are know to stimulate high levels of serotonin are: MAOIs, TCAs, SSRIs, SNRIs, Bupropion, Tramadol, Fentany, Oxycodone, Hydrocodone, MDMA, MDA, Amphetamine, Sibutramine, Crack, Triptans, LSD, Panax Ginseg, Nutmed, Yohimbe, Syrian Rue, Ritonavir, Granisetron, Olanzapine, Valproate, Buspirone, Lithium, Linezolid, Dextromethorphan, Risperidone, Trypthophan, L-Dopa, Valproate, Pep pill. For the reason that serotonin toxicity it's certainly not tested in the laboratory for diagnosis, signs are the one need observed. The greatest set of criteria to use to diagnose serotonin toxicity is Hunter Serotonin Toxicity Criteria.

Treatment for serotonin syndrome are as follows: discontinuing drugs that created the overdose posible and drugs that can contribute administration of serotonin antagonist (eg. cyproheptadine) for sever cases of toxicity for agitation, muscle mass hardness and also seizure such as movements, benzodiazepines (Valium, Ativan) Intra venous fluids Because serotonin syndrome is certainly not an easy task to diagnose, protection is required for any serotonin drugs mixture of that might cause 5-hydroxytryptamine toxicity.

Dunkley, EJ, Isbister, GK, Sibbritt, D, Dawson, AH, Whyte, IM, The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity, QJM 2003; 96:635-642 Prator BC. Serotonin syndrome symptoms. J Neurosci Nurs. 2006 Apr;38(2):102-5. Ford MD, Clinical Toxicology. 1st ed. Philadelphia, Pa: WB Saunders; 2001:150, 522, 547, 550.

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