As long as you keep power to the airbag circuit, no, it won't mess with them. I don't personally even see a use for them, since they only deploy under certain conditions, and probably aren't as necessary for typical EV speeds.
IMO - they're xtra weight. You may see it differently than I do, but that's my .02 for ya.
Most of the HVAC system can go - you won't be using it, unless you install a ceramic heater in place of the heater core, or water cool your engine (very inefficient, and the engine probably won't get hot enough to worry about it.
The issues with removing interior are obvious - noise, vibration, heat.
Noise - The chassis is pretty solid, and doesn't xmit sound as much as a Honda CRX would, but it can still get pretty noisy in there on the highway. There are several things you can do to rid the noise, like replacing bushings, and using lower-noise tires (which usually are lower Rolling resistance as well, although not rated LRR)
Vibration - can usually be solved with little bits of paper, usually helps w/ the noise too.
Heat - not to fret - you don't have a 200 HP heater in front of you anymore, so remove the insulation as well. (This is only really a problem in the winter, and you won't likely be driving an EV through the winter enough to say so.)
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