Lift creates drag, and so does downforce. Some aerodynamic improvements (such as a kammback over your trunk) will reduce drag and lift at the same time, others (such as deleting cosmetic wings) will reduce downforce and drag.
Downforce and lift are mostly a distraction here. A few lbs added to or lifted from the tires will have a tiny effect on mpg. Pursue drag reduction whether it removes lift or removes downforce.
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