The engine you describe does exist. Large ship propulsion two strokes are build that way including the super charging. But they run only as far as I know 102 rpm. The most difficult part in a small engine application is the exhaust valve drive. It is running double speed compared with four stroke cycle (small valve lift and more valves could be the solution) and the valves have also more heat load.
http://people.bath.ac.uk/ccsshb/12cyl/