I looked at Google Maps and saw the two routes you mentioned. Having just done part of the drive a month or two ago (So Carolina to Pittsburgh), I can testify that the West Virginia interstates are extremely wide (6 lanes in a lot of places,) and you'll have no trouble getting a lot of good coasting opportunities downhill, and at the same time not worry about cars/trucks getting on your rear when DWL'ing uphill because of the third lane. They are incredibly well-maintained and not very heavily traveled.
I do not have any experience with winter driving in those areas, but I suspect the roads will be clear (I'm sure Bob Byrd will have arranged for the rest of the country to pay to keep the roads clear, so might as well take advantage of it!)
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