Ok, well, I was half serious in that post... and half mocking.
The serious part doesn't see much of a net gain by moving the cooling system to the rear of the vehicle, because there will still be a good bit of turbulence, and you'll be adding weight for the lines, extra fluid, more drag on the engine because the water pump is now moving a larger volume of fluid, etc.
Weighing the good against the bad, I can't see a reason not to try it, though, especially if you can vent your cooling airflow into the wake area, where it might act like a virtual boat tail, filling the area of negative pressure behind the car.
You could also take your cooling flow from the wheel wells, as you suggested, which means that undercar flow could be directed toward the wheel wells while still maintaining a fairly clean profile along the sides and top of the vehicle.
I'd like to see what Aerohead has to say to this effect, though. He's got a few more miles of experience with aero and fluid dynamics than myself, and I'm going on intuition alone with a lot of unanswered variables.
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