I've tried to hypermile on it and failed, it's hard to coast with the wet clutch and I live in an area with alot of stop signs and stop lights that are poorly timed, so when I take it on longer trips my mileage tends to stay about the same.
The change in gearing didn't seem to hurt my mileage as far as I can tell, as running wide open with the old gearing pushed the engine RPM up to just over 10,000RPM and it has a 9,500 RPM red line, so the engine was much happier and seemed to run better.
If you want to head out on the interstate you legally are going to need a 250cc engine or larger, if you want to a larger engine like that I would look at one of the fuel injected 250cc motorcycles that just came out in the past year or so, or get a 250cc vespa engine that is fuel injected.
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