This is how I travel...shortest route from city/Point of Interest to city/POI. Nice compromise between the absolute fastest and the most scenic with the shorter distance usually making up a little for the slower speeds. Of course, my mileage is usually a lot better too and I see areas that mos outsiders never even hear of.
For example, I bought my truck in Richmond, VA then took backroads to Roanoke (through Appomattox), then to Asheville and Atlanta....I think we spent maybe an hour total on the interstate.
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