Your mileage is already good. A 40% drop is fairly common as a rule of thumb. If those are IRS deductible miles, then all the better. A 25% drop over 300-miles would cost about $12. It's just overhead added to the cost of goods.
As to mileage, weigh the trailer empty and loaded. Same with truck. Be sure trailer has brakes per law on weight, and/or WD hitch properly set up. Have trailer axle aligned. Brakes/bearings services. Radial tires no more than 5 yrs old. Tire pressures -- all of them -- according to Pressure & Load Tables (+20% if you want, or no less than vehicle manf numbers). Etc. Ck truck for brakes, bearings, etc. Run along just under 60 mph on limited access roadways.
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