As far as WOT, it's harder to do damage running lean on E85 than gas. I'd personally give the ECU plenty of time to adjust and re-map its tables, then make a single WOT run, listen for pinging, and pull the spark plugs after to make sure all looks well. If it's running lean enough to do damage, the plugs should tell the tale.
If the ECU needs help remapping enough, do like the turbo guys would and up the fuel pressure, as that allows more flow through a given injector. That would have it pulling fuel on E0 (rather than at baseline), but able to add enough on E85.
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Call me crazy, but I actually try for mpg with this Jeep:
Typical driving: Back in Rochester for school, driving is 60 - 70% city
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