You know the Hypermiling gods are against you if...
... You always have to drive uphill. Bummer
OK, seriously: Unless your commute is in an alternate, Escher universe, then you'll have to go down sometime.
What goes up, must come down. If your commute is uphill one way, then the return must be downhill. Then you can coast in neutral or coast in gear, depending on how steep the grade is. When neutral coasting your engine is at idle, so it uses some fuel, but less than during normal driving. When coasting in gear (
DFCO) your engine mostly likely doesn't use any fuel, but also you won't coast as far.
So, if you have to use more fuel going one way because of an uphill, then you will have a chance to use less fuel on the way back.