I'd be surprised if the silencer makes any noticeable difference on vs off. Backpressure isn't the key (unless it's excessive), fast, linear flow is what matters.
There are calculations that can be done to find the optimal header size and length, optimal pipe size, etc.
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Call me crazy, but I actually try for mpg with this Jeep:
Typical driving: Back in Rochester for school, driving is 60 - 70% city