I think your best bet for hypermiling in an SUV would be the Escape hybrid. Highest I've seen anyone get in those was about 39mpg. But honestly, I'd talk her into the xB since it's cheaper and would allow for a few mods to be added.
If at all possible go test drive both and see what you're more comfortable with. I'm sure you can apply any hypermiling tips to both and beat the EPA. And test out a Prius to see if it has enough head/leg room for you. If it doesn't, next years model is supposed to be a bit bigger if you're willing to wait that long.
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