My first suggestion would actually be VW Jetta or current generation BMW diesel. They're tough, give consistent mileage, and are all large enough.
If you have an aversion to diesel, or it's prohibitively expensive where you live, then I'd have to suggest Nissan with a small displacement engine or a used electric if you're trips are short enough and you don't mind tinkering.
You average home converted electric has a range of about 40 to 50 miles, round trip, so if you most of your wife's destinations are with 20 miles of home then the electric is a great solution. If you have to go farther regularly, then the Nissan would be be the better choice over the long haul.
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