A motorcycle engine & drivetrain is designed to move a 600 - 800 lb vehicle/rider and a car engine & drivetrain is designed to move a 2500 - 5000 lb vehicle/passangers. If you build a 800 to 1000 lb car, a motorcycle engine & drive train would be fine. most motorcycle engines do not like to run below 3000 rpm in top gear, in contrast my 1500cc 4 cylinder Yaris car engine is quit happy at 1500 rpm accelerating in 5th gear.
Many cars have a Cd of 0.3 to 0.4, most motorcycles have a Cd of 0.65 to 0.9, even the sport bikes are in that range aerodynamicaly. The sport bike fairings adds almost nothing to the aerodynamics of a motorcycle.
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