It should help your highway MPGs, after you take into account that you are traveling farther than your odometer shows. (Old tires ~= 22.6" diameter, new tires ~= 25.5" diameter.) Each mile on the odometer will be about 1.13 miles actual distance.
Effects in the city probably depend more on your driving style than on the exact tire/wheel diameter.
Expect the car to feel less peppy when accelerating at a given speed.
-soD
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