[LeanBurn]

I was more after whether the air moving down the side of the car would get caught on the wheel well right under the side mirrors or would having the tire more outwards would minimize/eliminate it, not so much how much turbulence the wheel itself created. If it was as the drawing above suggests the "fan-like" turbulence created by the wheel would push the air to more align with the rest of the body side that would be great. If the fan-like turbulence is negligible then there is more of a chance the air gets snagged on the wheel well, creating drag. If the wheel was pushed out to more in line with the body air would have less of a chance to get caught there.