Note that in some cases the taller gearing from larger wheels and tires more than makes up for the extra weight and frontal area. There's a thread around here somewhere about a guy who put very large wheels on his Scion xB and saw a very noticeable increase in highway MPGs without much if any loss in the city. (Part of which I assume is down to driving technique.)
Testing would tell you which is better, but that would cost some money for the new tires for your small rims...
-soD
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