Pull the 1/4 panel interior trim so you can get to the inside of the rusted areas. Remove every speck of the existing rust. Use Marine Tex for a filler, it's waterproof. Then go around the wheel arch on the inside and use a good sealer to seal off the area from future rust. Never use bondo to fix rust, it's not meant for that purpose.
I used to weld up and repair rust like you are describing, and I have fixed a heck of a lot worse that that including structural repairs, but I am old and sold my shop and gave my MIG welder to my friend to use in his shop.
regards
Mech
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