I drive 350 miles each way twice a week back and forth (Fridays and Sundays) between work and home. It's about six hours, and not too bad. I get a chance to relax, talk on the phone to friends and family and listen to some great talk radio via iHeartRadio on my Android phone.
Yes, I would prefer not to do it, but its now second-hand, and the time flies by...even at 67mph and 67mpg.