For the two sizes you listed I would stick with the 215/60/17 for the narrower footprint and comfort.
BestMPG = Bridgestone Ecopia EP422
Best Traction and value = Continental ProContact with EcoPlus
GoodMPG and traction and value = Yokohama AVID Ascend
The jury is out on the Defender because no one has them yet so we don't know how well they do for mpg.
Make sure you consider price and treadwear warranty when looking for tires. Sometimes a high mpg tire suffers a low treadwear which may make it cost more to run than say a tire with a little less mpg but much higher treadwear. The Ecopia EP100 and the AVID Ascend are good examples of this.
Some great LRR tires do suffer from worse traction or handling but not all. The Energy Saver A/S offers stellar mpg but poor handling and ok traction. The AVID Ascend and ProContact with EcoPlus offers less mpg (but more than a non- LRR tire) but better handling and traction in the wet. I have run or had direct experience with the above tires.
I chose the Energy Saver A/S for total economy but if it wasn't available I would have stuck with the Ascend or the EP422.