Yes, the heavy (75%+) E85 blends knock power down some especially when cold, but it's a YMMV thing; in the car I notice it more but the F150 doesn't seem to care how strong the blend is. I strongly suspect the F150 has more "bandwidth" as far as the ECU and the EFI's ability to richen/lean the mix. It hasn't been an issue even in the car as it is usually very lightly loaded and driven on flat lands.
50/50 or weaker blends in either vehicle are basically indistinguishable from regular in both power and mpgs (except for my usual caveat that, if you have -40F temps, leave the ethanol out).
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