3-wheeler
You got me thinking... so the solution would involve how/where to distribute the load over as large an area as posible of the riders body. So the feet could be suported under the heel rather than on a foot peg under the ball of the foot, this would take half of the leg weight off the bum.
The seat would also need to be made as wide as posible and go as far under the thighs as the movement of the legs would allow. If the rider is able to be leaned back then the load bearing area would be increased, although the distance from the handle bars may not permit this unless a remote steering head is used.
Michael Moore
Good point about the ground clearance of the feet. This would suggest that a fairly high foot position is inevitable unless the feet are positioned close together.