You definitely want a easy/quick release/lock system. Since you have a pickup truck, you don't want to attach the skirts to the cab portion or the flex will start popping things.
As I progress in my aerodynamic trials, I've found that I have to build a separate support system fer my rear wheel skirts apart from my side skirts which are attached to the main frame. I'm looking to morph the wheel skirts into my rear wheel strakes, too...