If it were lighter, perhaps. But I can't imagine it would be more than 0.5% overall improvement, so unless you're getting the one-piece shaft cheap enough that you can swap it just to check (with A-B-A testing and number crunching), I'd say it's not worth it.
Maybe look into finding a Ford Ranger rear end with gearing appropriate to your commute? I don't think a rear end swap would be substantially more cost than a driveshaft, but the efficiency improvement would be.
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