It might help if one is more specific as to load & rpm. Highway, or stop & go in a regional metro? Then (as always) the comparison of truck spec, climate, terrain and specfic vehicle use.
Diesels are less weight-sensitive than gassers (high compression and higher torque versus higher horsepower), true, but determining optimal running spec is about the above factors plus keeping highway travel speed at or below 60-mph (as horsepower demand rises very fast from that point).
The mechanical baseline on a heavy pickup is highly important (brake drag, alignment, steering wander, tire pressure, bearing pre-load, etc), and for a T/C engine, being certain of no CAC leaks, etc.
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