Allegedly, Isaac Asimov wrote a joke book, and this joke supposedly came from it. I have told it several times and the other person always laughed, but misinterpreted the punchline:
Dave walks into a bar and sees Joe sullenly sipping a beer. He immediately rushes over, sits down, and asked him what was wrong.
"My wife ran off with my best friend."
"But Joe! I am your best friend!"
With an enormous grin, Dave responds "Not anymore!"
Um... Refuge? Will you please insult men now?