Assuming you are looking at radial because bias is a whole nother can of worms.
The stiffer sidewall will negatively effect braking and cornering.
Trailer tires are not manufactured for wet conditions.
Trailer tires are notoriously difficult to balance.
I've pondered the same thing. I'd give it a try for a car that sees low speed urban driving or largely rural roads under 55mph. I don't think I would feel safe in faster congested traffic.
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