Get a 250, and do even a few mild aeromods. the boattail trunk is a great one, since it is luggage as well as aero. the Ninja, and the CBR250 will manage 80ish mpg and 80mph quite well. most of the 250 cruiser style bikes won't, although if you changed the gearing they might. the honda rebel for instance redlines at 80mph in top gear. if you are interested in a fairing or trunk, take a look at Craig Vetter's work. Also I am looking to have my own design finished for this summer. I can go freeway speed on a 14hp 185cc bike with fairing and tail in place, and still get over 100mpg. I have a thread here on the project
http://ecomodder.com/forum/showthrea...ike-23987.html
Lowering rpms at speed also makes a difference in engine wear. I run 25% taller gearing on my bike meaning that the engine is now turning the same speed at 75mph as it did at 55mph stock. This reduces wear on the engine, and in combination with better aero gives better FE. (note that this aggressive of a gearing change is only advised in combination with matching aero improvements).