What is your budget ?
If not tight, the new Honda 700 is your best bet since it is tune for FE.
Personnaly, to cruise around at 80 mph, I"d take at least a 500 faired bike and make it pull as big a gear reduction ratio as available over the counter.
But for longer trips, maintenance quickly start to be an issue so belt or shaft drive are a must.
Older design 2 valvers seem to have an advantage like Ducati's or Harleys.
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