This strikes me as pretty mild for a re-imagining of the internal combustion engine. Ponder this:
I just discovered the Scuderi design, and found the thread through the forum search.
I view everything through the prism of "how would it work with a Volkswagen boxer 4". This looks pretty doable to me:
- paired cylinders? check.
- unequal size cylinders? no problem. Separate 'jugs'.
- connect the two cylinders? choose between the single port and dual port head.
The single port intake would be adequate to accommodate the air hybrid feature, but if better breathing is needed for an intercooler, the dual port head is more available.
Two exhaust ports would become the new intakes. The hardest problem I see is positioning the turbo since the intake and exhaust are at opposite ends of the engine, but it's no worse than a cross-flow head, I guess.
The biggest problem to solve would be the custom ~20° offset crankshaft in billet steel.
I could post about this over at thesamba.com, but I'll let everyone tell me how wrong I am before I do.