I don't really ever go on vacation, however, when I do, I usually travel by train because the amount of fuel used per person on the train is actually really really good in comparison to other forms such as airplanes and buses. Not to mention, trains are really fun, it's like a little moving city with internet (assuming you have those cell phone internet things) and power outlets for your laptop, etc. However, aside from how I get to my destination, the only thing I really try to do is stay at a hotel that is reasonably close to the train station so long as it's still reasonably distanced to where I want to visit while I'm there. For example, I'm going to New York next month VIA amtrak, riding into Penn station and staying in the Hotel Pennsylvania which is right across the street, yet still in the heart of everything I want to see while I'm there. That way I don't have to get too many taxis and I can walk as much as possible.
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