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It depends on how comfortable you are with blow-outs and mounting the spare. I have no problem with either and willingly run tires until they blow so as to extract the last mile outta 'em. Just make sure the spare is aired up and the jack and lugwrench are on board.
I recently had a tire with very nice tread depth develop a slow leak, which gradually became less slow. Turns out it was leaking through sidewall weatherchecks. There is also quite a bit of cracking down between the tread blocks. To heck with that, I'm gonna run that sucker some more, so I had a tube put in. I know that raises r.r. some miniscule degree but getting the use out of that tire is more important to me.
P.S. As far as the locked caliper goes, don't be afraid to grease the guide pins. I do it whenever I'm in there servicing brakes. The key is to not use so much grease that it can migrate onto the pads or discs.
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