Not really. The purpose of getting better fuel economy must be coupled with getting useful work done. (The best fuel economy is probably a human-powered bicycle or similar. And that would be pretty useless work.)
If anyone is trying to get better economy, and he is driving by himself in a vehicle with more than one passenger space, he does not understand the concept of real energy savings to begin with. We are then just playing around with little bits and pieces of the puzzle. Interesting maybe, but not particularly helpful over all.
After all, don't people go to a lot of extra work to make their cars more aerodynamic? That just usually adds weight. It would be far better to shrink or expand the vehicle based upon space needed.
If one is not going to do that, then calculations of weight when adjusting tire pressure are a very reasonable part of the formula. Today I might just be driving myself, but tomorrow I might be taking the family and a full car of vacation stuff on a very long trip.
We can no more ignore weight then we can aerodynamics or rolling resistance or time or speed or any other part of the equation. Weight will always play a part in the whole discussion; especially when considerations of tire wear are concerned.
BTW, it is actually an eco-mod forum.