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We have had pesticide/herbicide resistant weeds since we started using them.
Toxin resistance predates laboratory-based genetic engineering.
Just as genetic manipulation of food crops and animals predates laboratory-based genetic engineering.
The only difference is, with specific genetic insertion, you avoid all the other genetic anomalies and side-effects created by intensive cross-breeding and monoculture.
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And, as I've pointed out earlier in this thread, there are non-profits that carry out this research and who don't pursue the same cut-throat agenda as certain companies do.
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