New emissions are very strict. Engines stay in closed loop until 4k RPM and 75% load these days. A lot of tuning is to protect the catalyctic converters. But for open loop operation, yes. Flame speed and combustion stability can be a significant factor.
Now I have seen some Ford research on E85 in turbo and naturally aspirated engines. There is one where they tested the 3.5L Ecoboost and another they tested the new Coyote 5.0L. I believe they discussed these same factors.
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-Allch Chcar
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