I might be wrong but your target throttle position on cruise is more 75% rather than full throttle because there might be richer setup for cooling / reliabillity at full throttle.
Anyway, I think I understand your point of view but I feel if you want to keep revs down with at least some efficiency, you need to alter engine internals.
Best exemple is the EL 250 (custom declination of EX) is around 45 mpg stock when a GN is 70 and up.
Their engine is not efficient FE wise, it is tuned for power.
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