I wouldn't think that turbocharging it would be needed. Unless you're swapping it into something large and heavy, in which case you can use the turbo'd VX engine to replace a much larger and less efficient motor...
One thing to think about: When you drive for economy, you are running at relatively low RPM. Low revs means that knife-edged cranks, boat-tailed mains, etc., will have much smaller effect than in a race car.
-soD
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