If you are carying luggage on your road trip. A tail case will be better than panniers. You could even build an aero trunk without too much trouble. Just start your trunk the same width as your body, and taper it toward the rear. At the least this will allow you to carry your stuff without hurting your mileage. Tires are going to make little difference on the open road, as a bike suffers from such horrendous aero, but they may help in the city at lower speed.
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