[spacemanspif]

Is the programmer the type with pre-loaded maps or can you make custom ones? For some reason programmers aren't very popular on this site; it could be because they are expensive. Might be able to play with the fuel MAP if you can do custom but make sure you are able to monitor EGT and other critical data so that you don't implode the engine with a bad tune. Water/Meth might also give you a little bit of a boost but can be expensive.

Sorry to tell you, but that truck is HUGE and running around in the city with that big and heavy of a truck is never going to yield good economy unless you shut down a lot but you probably have an auto that isn't P&G with EOC friendly.

Do you do much off-roading? probably not with it being 2wd, a drop kit would help the economy. If you can't figure out a belly pan, consider an air dam (should be plenty of barn doors in TX lol) and side skirts as the next best option.