Worth it in dollars? Not unless you can score the stuff for nearly free.
Worth it in saved fuel? Probably won't be able to detect the fe increase- you'd just have to take it on faith that it's a little better. Or let the placebo effect do the work.
I've done both- run with the spare and without. Depends on the situation. On the Tempo I've run old junkyard tires 'til the cords show or they blow; in that case I need a good spare and tools on board. But on the vehicles with tires I bought new, I am comfortable with my "flats history" i.e. the odds of an issue are super low, such that I'll run with no spare then. I like to run with no spare when I'm utilizing ALL the trunk space- wow is the trunk ever bigger w/o the spare and the tools.
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