2k rpm at 65 is about right, IMHO. 4.10s were great when the speed limit was 55, the rpms would be down to a nice 1750 or so. Today 4.10s are for towing/hauling and not great for highway MPGs unless you are using oversize tires and the gears are for compensation. So... 4.10s with stock tires, your MPGs will fall off over 55 mph. Over 2k rpm, all bets are off - expect low fuel mileage.
IMO, I wouldn't drive faster than 65 mph with 4.10s. I've had two trucks with 4.10s and some with taller gears. If MPGs are a concern to you, then your best and cheapest bet is to drive a little UNDER the speed limit. But if getting from point A to point B in the least amount of time, time is money, running late, etc is the name of the game, then MPGs gets thrown out the window. Up to you.
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