Well, since this thread is now been reopened after several months of inactivity......
The most efficient tire size is larger. That is, from the point of view of rolling resistance, drag, etc, the larger the tire, the better. Unfortunately, there is a down side, in that there is only so much room under the fenders.
Unfortunately, tire size is NOT a large factor when it comes to fuel economy. Things such as tread compound is much larger, so it pays to spend time trying to find the compromise that works best for you. Treadwear, traction, and rolling resistance are in opposition to each other.
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