Sounds like an interesting project for sure! My only concern for you is getting all the electronics for both the engine and transmission to be friends.
I will be doing something similar in the next decade. My dad has a '64 chevy stepside that has been sitting in their barn since before i was born ('89). Since there is no money in restoring it to factory, I will be installing a v6, probably turbo charged and a 6speed tremec. 3300 lbs stock. Though when I build this truck I won't nearly as concerned with mileage as fun.
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