relatively low pressure(for fuel injection) and returnless is asking for vapor-lock.
also consider that you'll need to figure out some kind of magic for the tank cap... it's vented to allow air to be drawn into the tank so that a vacuum isn't created and stops fuel from flowing. with a highly pressurized tank, the cap is either going to vent all of the pressure or all air that gets into the tank is going to have to come from the compressor.
also keep in mind, running a static fuel pressure will cause significant changes to fuel flow with changes in manifold pressure.
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