Most will tell you not to risk it. I'd say it's safe as long as the rim never rode on the sidewall or tread while it was low on air.
I've got a tire with a plug and a sidewall tear like the one pictured, and it has been running fine at 44 psi for years.
Run it up a little over sidewall max, and if it doesn't blow, it should safely run at pressures lower than that.
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