There are no gains due to disconnecting the front driveshaft. The transfer case and the front differential both have electronic disconnects, thus the front drive shaft is not spinning when the truck is in 2WD. Note everything outboard of the front differential on the front end is spinning, such as your CV joints, and due to the function of the front axle disconnect some components within the differential are also spinning. Slight gains could exist for swapping over to lockable/un-lockable hubs like the older Tacomas had.
I have no direct experience with the V6, but I have some opinions. I will type them out here when I have time.
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