Recently, the transport industry is evolving quite fast; aerodynamic, lightweight aluminum & composite structures, efficient hybrid engines and autonomous tractors. Most likely, intermodal cargo container designs would be specialized; transoceanic (saltwater exposure, strong but heavy designed for multiple-level stacking), efficient long road (more lightweight) travel and for air-borne (ultra-lightweight fabric covered palletized flatbeds) transport. Air cargo integration ; just integrate pallets' (ultra-lightweight) structures with the plane's frame, smooth out the pallets' bottom and seal a plane around it.
Not really a new idea...
http://images.fineartamerica.com/ima...rek-images.jpg
http://cdn-www.airliners.net/aviatio.../6/0141605.jpg
http://www.sikorskyarchives.com/imag...64%204edit.jpg
A few years back, Northrop Grumman had a stealth blended wing cargo concept.
http://defensetech.org/wp-content/up...g1-490x371.jpg